Argentina coach Daniel Hourcade says his team must make the Springboks uncomfortable at Loftus on 16 August.
Cobus Reinach has been called up to the Springbok squad for the Rugby Championship, while Coenie Oosthuizen, Siya Kolisi and Johan Goosen have been dropped.
A rejuvenated Dan Carter is one of three additions to New Zealand's squad for the Rugby Championship.
Fijian-born wing Henry Speight has been included in the Wallabies squad for the Rugby Championship.
Fourie du Preez will miss the entire Rugby Championship following an ankle injury sustained against Scotland.
Argentina have confirmed that their home Test against the Springboks on 23 August will be played in Salta.
Saracens lost their place at the top of the English Premiership log with a surprise 22-13 defeat by lowly London Irish.