Rob Evans and Tomas Francis will start for Wales against England in Cardiff on Saturday.
Taulupe Faletau is the only personnel change from the match 23 against Italy and he is named on the bench.
'Both Rob and Tomas made a big impact off the bench last weekend and deserve their opportunity to start,' said Wales coach Rob Howley. 'We have had a short turnaround but Dan [Biggar] and George [North] have worked hard with the medics and we are pleased to be able to name them.'
Wales – 15 Leigh Halfpenny, 14 George North, 13 Jonathan Davies, 12 Scott Williams, 11 Liam Williams, 10 Dan Biggar, 9 Rhys Webb, 8 Ross Moriarty, 7 Justin Tipuric, 6 Sam Warburton, 5 Alun Wyn Jones (c), 4 Jake Ball, 3 Tomas Francis, 2 Ken Owens, 1 Rob Evans.
Subs: 16 Scott Baldwin, 17 Nicky Smith, 18 Samson Lee, 19 Cory Hill, 20 Taulupe Faletau, 21 Gareth Davies, 22 Sam Davies, 23 Jamie Roberts.
Photo: David Rogers/Getty Images