Hallam Amos and George North will start on the wings, with Alex Cuthbert dropping to the bench, when Wales take on England at Twickenham on Saturday.
Wales coach Warren Gatland has made nine changes to the team that beat Uruguay in their opening World Cup match, with Gareth Davies and Dan Biggar named at halfback, while Jamie Roberts and Scott Williams will partner in the midfield.
Among the forwards, Dan Lydiate is preferred to Justin Tipuric on the flank and Taulupe Faletau will start at No 8, while prop Gethin Jenkins will make his first appearance in his fourth World Cup, with Scott Baldwin and Tomas Francis completing the front row. Bradley Davies and Alun Wyn Jones will pack down in the second row.