Odwa Ndungane will start at fullback for the Sharks against the Lions at Ellis Park on Saturday.
Ndungane comes in for the injured Willie le Roux, who is also serving a one-match suspension for foul play in the Boks' third Test against Ireland.
Garth April is back at flyhalf in place of Pat Lambie, who is still battling with a concussion.
On the bench, former Pukke and Leopards fullback Rhyno Smith will make his Super Rugby debut if he comes on, while S’bura Sithole and Tera Mtembu could make their Super Rugby return.
Sharks – 15 Odwa Ndungane, 14 JP Pietersen, 13 Paul Jordaan, 12 André Esterhuizen, 11 Lwazi Mvovo, 10 Garth April, 9 Michael Claassens, 8 Philip van der Walt, 7 Jean-Luc du Preez, 6 Keegan Daniel, 5 Stephan Lewies, 4 Etienne Oosthuizen, 3 Lourens Adriaanse, 2 Franco Marais, 1 Beast Mtawarira (c).
Subs: 16 Chiliboy Ralepelle, 17 Thomas du Toit, 18 Coenie Oosthuizen, 19 Ruan Botha, 20 Tera Mtembu, 21 Stefan Ungerer, 22 Rhyno Smith, 23 Sibusiso Sithole.
Photo: Rob Jeffries/Getty Images