Ireland coach Joe Schmidt has made 14 changes to his starting XV for Saturday’s match against the USA in Dublin.
Outside centre Garry Ringrose is the only surviving starter from the win against the All Blacks.
The team will be captained by flanker Rhys Ruddock, while Munster centre Sam Arnold will make his Test debut if he comes off the bench.
Ireland – 15 Will Addison, 14 Andrew Conway, 13 Garry Ringrose, 12 Stuart McCloskey, 11 Darren Sweetnam, 10 Joey Carbery, 9 John Cooney, 8 Jack Conan, 7 Jordi Murphy, 6 Rhys Ruddock (c), 5 Iain Henderson, 4 Tadhg Beirne, 3 Finlay Bealham, 2 Niall Scannell, 1 Dave Kilcoyne.
Subs: 16 Rob Herring, 17 Cian Healy, 18 John Ryan, 19 Quinn Roux, 20 Josh van der Flier, 21 Luke McGrath, 22 Ross Byrne, 23 Sam Arnold.
USA – 15 Will Hooley, 14 Blaine Scully (c), 13 Bryce Campbell, 12 Paul Lasike, 11 Marcel Brache, 10 Will Magie, 9 Shaun Davies, 8 Cam Dolan, 7 Hanco Germishuys, 6 John Quill, 5 Nick Civetta, 4 Greg Peterson, 3 Paul Mullen, 2 Joe Taufete’e, 1 Titi Lamositele.
Subs: 16 Dylan Fawsitt, 17 Chance Wenglewski, 18 Dino Waldren, 19 Samu Manoa, 20 David Tameilau, 21 Ruben de Haas, 22 Gannon Moore, 23 Ryan Matyas.
Photo: Inpho