Ellis Jenkins will captain a largely second-string Wales team against Tonga in Cardiff on Saturday.
Lock Adam Beard is the only player to keep his place in the starting XV from the victory against the Wallabies last weekend.
British & Irish Lions duo Liam Williams and Dan Biggar return to a backline that includes uncapped fullback Jonah Holmes, while Scarlets wing Steff Evans also gets a start.
Loosehead prop Wyn Jones makes his first start for Wales alongside Dragons duo Elliot Dee and Leon Brown and there is also a first start for No 8 Aaron Wainwright.
Wales– 15 Jonah Holmes; 14 Liam Williams, 13 Tyler Morgan, 12 Owen Watkin, 11 Steff Evans; 10 Dan Biggar, 9 Tomos Williams, 8 Seb Davies, 7 Ellis Jenkins (c), 6 Aaron Wainwright, 5 Adam Beard, 4 Jake Ball, 3 Leon Brown, 2 Elliot Dee, 1 Wyn Jones.
Subs: 16 Ryan Elias, 17 Rob Evans, 18 Tomas Francis, 19 Cory Hill, 20 Ross Moriarty, 21 Aled Davies, 22 Rhys Patchell, 23 Josh Adams.