Trevor Nyakane and Beast Mtawarira will both start for the Springboks in the crucial Rugby Championship match against Argentina in Salta on Saturday.
Nyakane and Mtawarira replace Frans Malherbe and Steven Kitshoff, respectively, after being named on the bench for the draw with the All Blacks.
Bongi Mbonambi also gets a starting berth with Malcolm Marx switching to the bench in the only other change to the starting lineup.
Pleasingly for Rassie Erasmus, scrumhalf Faf de Klerk has passed his HIA after suffering a concussion in New Zealand.
The Springboks lead the Rugby Championship standings by one point and can claim the trophy with a bonus-point win over Argentina.
Springboks – 15 Willie le Roux, 14 Cheslin Kolbe, 13 Lukhanyo Am, 12 Damian de Allende, 11 Makazole Mapimpi, 10 Handré Pollard, 9 Faf de Klerk, 8 Duane Vermeulen (c), 7 Pieter-Steph du Toit, 6 Kwagga Smith, 5 Franco Mostert, 4 Eben Etzebeth, 3 Trevor Nyakane, 2 Bongi Mbonambi, 1 Tendai Mtawarira.
Subs: 16 Malcolm Marx, 17 Steven Kitshoff, 18 Frans Malherbe, 19 RG Snyman, 20 Francois Louw, 21 Herschel Jantjies, 22 Frans Steyn, 23 Jesse Kriel.
Photo: Gavin Barker/BackpagePix