New Zealand-born Bundee Aki will make his Test debut when he starts at inside centre for Ireland in Saturday clash against the Springboks in Dublin.
Aki, who qualified via residency, will start in the midfield alongside Robbie Henshaw, while Connor Murray and Johnny Sexton will form an experienced halfback pairing.
Rob Kearney, Andrew Conway and youngster Jacob Stockdale will make up the back three.
As expected among the forwards, South African-born CJ Stander will start at No 8, with Sean O’Brien and Peter O’Mahony on the flanks, while the tight five is packed with experience.
Ireland – 15 Rob Kearney, 14 Andrew Conway, 13 Robbie Henshaw, 12 Bundee Aki, 11 Jacob Stockdale; 10 Johnny Sexton, 9 Conor Murray; 8 CJ Stander, 7 Sean O’Brien, 6 Peter O’Mahony, 5 Devin Toner, 4 Iain Henderson; 3 Tadhg Furlong, 2 Rory Best (c), 1 Cian Healy.
Subs: 16 Rob Herring, 17 Dave Kilcoyne, 18 John Ryan, 19 James Ryan, 20 Rhys Ruddock, 21 Kieran Marmion, 22 Joey Carbery, 23 Darren Sweetnam.