Joe Pietersen will start at flyhalf when the Cheetahs face the Stormers at Newlands on Saturday.
The former Stormers utility back has recovered from the injury that's kept him sidelined for the past couple weeks and assumes the No 10 jersey from Francois Brummer.
Meanwhile, Sergeal Petersen has been drafted in to start at right wing, replacing Springbok Cornal Hendricks.
The final change sees Tienie Burger take over from Carel Greeff on the side of the scrum after recovering from injury.
The match will be coach Naka Drotské's last in charge, with Franco Smith set to step into the role for the final two matches of the season.
Cheetahs – 15 Clayton Blommetjies, 14 Sergeal Petersen, 13 Francois Venter, 12 Michael van der Spuy, 11 Raymond Rhule, 10 Joe Pietersen, 9 Tian Meyer, 8 Willie Britz, 7 Boom Prinsloo, 6 Tienie Burger, 5 Francois Uys (c), 4 Carl Wegner, 3 Maks van Dyk, 2 Torsten van Jaarsveld, 1 Danie Mienie.
Subs: 16 Stephan Coetzee, 17 BG Uys, 18 Ewald van der Westhuizen, 19 Steven Sykes, 20 Henco Venter, 21 Sarel Pretorius, 22 Coenie van Wyk, 23 Rayno Benjamin.
Photo: Steve Haag/Gallo Images