Vodacom Bulls hooker Callie Visagie and wing Akona Ndungane have been ruled of Saturday's Super Rugby match against the Force at Loftus.
Visagie has a chest injury, while Ndungane will be sidelined for a month after breaking his hand.
Flyhalf Jacques-Louis Potgieter, who missed the last match against the Cheetahs due to a hamstring strain, will train on Tuesday and should be fit to be considered for the weekend.
Meanwhile, Blue Bulls flanker Roelof Smit injured his ankle against the Leopards XV and will be out of action for a week or two.
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