Keith Earls has returned to Ireland's starting XV for their match against England at Twickenham on Saturday.
Earls replaces the injured David Kearney on the left wing, while Robbie Henshaw switches to 13 in place of the injured Jared Payne and the uncapped Ulster centre Stuart McCloskey starts at 12.
The rest of the changes are among the pack. Mike Ross starts at tighthead prop ahead of Nathan White, lock Donnacht Ryan has been promoted from the bench to replace the injured Mike McCarthy and the flanker Sean O’Brien is replaced by debutant Leinster flanker Josh van der Flier.
Ireland — 15 Rob Kearney, 14 Andrew Trimble, 13 Robbie Henshaw, 12 Stuart McCloskey, 11 Keith Earls, 10 Johnny Sexton, 9 Connor Murray, 8 Jamie Heaslip, 7 Josh van der Flier, 6 CJ Stander, 5 Devin Toner, 4 Donnacht Ryan, 3 Mike Ross, 2 Rory Best (c), 1 Jack McGrath.
Subs: 16 Richardt Strauss, 17 Cian Healy, 18 Nathan White, 19 Ultan Dillane, 20 Rhys Ruddock, 21 Eoin Reddan, 22 Ian Madigan, 23 Simon Zebo.
Photo: Paul Gilham/Getty Images