Luke McLean has replaced David Odiete at fullback for Italy's match against England in Rome on Sunday.
Odiete injured his neck against France last weekend and has not recovered in time.
There are two changes to the bench, with uncapped South African-born flank Abraham Steyn replacing Dries van Schalkwyk and flyhalf Edoardo Gori coming in for Kelly Haimona.
Italy – 15 Luke McLean, 14 Leonardo Sarto, 13 Michele Campagnaro, 12 Gonzalo Garcia, 11 Mattia Bellini, 10 Carlo Canna, 9 Edoardo Gori, Sergio Parisse, 7 Alessandro Zanni, 6 Francesco Minto, 5 Marco Fuser, 4 George Fabio Biagi, 3 Lorenzo Cittadini, 2 Ornel Gego, 1 Andrea Lovotti.
Subs: 16 Davide Giazzon, 17 Matteo Zanusso, 18 Martin Castrogiovanni, 19 Valerio Bernabo, 20 Abraham Steyn, 21 Guglielmo Palazzani, 22 Edoardo Padovani, 23 Andrea Pratichetti.
Photo: Jean Catuffe/Getty Images